About the SCOT Study
More clinical research studies are needed to determine the best treatment for scleroderma. While organ-specific treatment is important and helpful, some experts believe that a broader and possibly more effective approach might be to treat the individual's immune system as a whole. SCOT study investigators will study two immune-based approaches:
- Stem Cell Transplant: High-dose immunosupression followed by stem cell transplantation
- High-Dose Cyclophosphamide (Cytoxan): Monthly intravenous Cytoxan for 1 year
Why Were These Approaches Chosen?
The initial idea for using stem cell transplantation comes from animal experiments, as well as observations from cancer patients who also had an autoimmune disease that improved after undergoing bone marrow transplantation. In most cases, their autoimmune disease went into long-term remission after the transplant. For the SCOT study, only autologous (self) stem cell transplantation will be used. High-dose immunosuppressive therapy is given and participants then receive back their own purified blood stem cells to restore their immune system.
High-dose Cytoxan is being studied because it has strong immunosuppressive properties. It reduces the numbers of immune cells thought to be causing scleroderma. Cytoxan has been used widely by doctors to treat autoimmune diseases, such as scleroderma and lupus. However, the dose being used in the SCOT study is higher than what doctors typically prescribe, and the length of administration is longer. The decision to test this dose is based on a variety of reports that have suggested that a higher dose may stabilize or improve symptoms of the disease. Specifically, it has been reported to slow down damage in the lungs caused by scleroderma.
For More Information
If you have additional questions about the SCOT study, please contact us at 1-866-909-SCOT or firstname.lastname@example.org.
Please note: This information on this web site is designed to help you understand a bit about the SCOT study. It should not replace your reading the full text of the study brochures and the consent form. You should read the entire consent form and ask any questions prior to participating in any study procedures.